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Recent studies have confirmed that bilirubin can prevent the loss of TH + dopaminergic neurons in vitro PD models by acting on TNF- , providing a mechanistic basis for related trials ( 5 Conclusion The significant rise in the number of patients with PD has rendered their clinical diagnosis and treatment increasingly challenging

Patients with PKLD have a greater symptomatic burden than those with isolated PLD and delays in presentation or diagnosis may contribute to higher PLD-Q scores

Asking open-ended questions about potential reasons to quit encourages change talk , allowing the patient to articulate their own arguments for smoking cessation rather than feeling pressured by the physician

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